As a revolver shooter and -toter, I sometimes encounter folks who deem the wheelgun a cute anachronism at best, a useless antique whose utility as a serious defense weapon has been eclipsed by the ascent of the flatgun, which can hold two or three times as many marbles in the tank.
Some arguments aginst the wheelgun have some validity, especially in comparison with the semiautomatic pistol. The wheelgun holds less rounds (usually--the difference in capacity between an eight-shot S&W 627 and a single-stack 1911 is negligible), it's slower to reload, and its larger bulk around the midsection makes it a little more difficult to carry inside a waistband.
One of the arguments that doesn't hold much validity, and one that I encounter quite frequently in revolver-versus-autoloader discussions, is the dreaded "multiple attackers" scenario.
"Criminals work in packs!" some folks will point out. "If you are faced with more than six attackers, you're screwed if you carry a six-shooter!"
Folks, I have news for you: if you get accosted by a half-dozen or more armed attackers who have any amount of skill and determination, your goose is cooked, regardless of what you carry in your holster. If you tote a plastic autochucker with a 19-round magazine, you're just as dead as I am with my six-shot Smith--the only difference will be that you'll die with more bullets in your gun.
My strategy in a multiple-attacker scenario would be to shoot the most belligerent one first, and then engage the remainder as needed with what I have in the gun, and hope that the sight of one or more of their buddies dropping will make the rest reconsider their plans for the evening.
Now, don't get me wrong: more bullets in your gun are never a bad thing. Nobody's ever been in a gun fight and found themselves wishing they had less ammunition in their weapon. However, there are tradeoffs with every weapon system, and I made the conscious choice to sacrifice capacity for the reliability and simplicity of the wheelgun. In addition, I find that I can simply put bullets on target most accurately and consistently with a S&W double-action revolver. I'm confident that my revolver a.) lets me put the rounds where they need to go better than anything else, and that b.) the gun is going to to bang every time I pull the trigger. In my mind, that's an acceptable trade for extra capacity.